hrp0089rfc12.1 | Diabetes and Insulin 2 | ESPE2018

Use of Acid-Suppressivemedications During Infancy and Early Childhood and Its Association with Type 1 Diabetes

Menon Sruthi , Umapathi Krishna Kishore , Thavaman Aravind , Bora Geetanjali , Davis Ajuah

Background: Type 1 diabetes is a multifactorial, immune mediated disease whose incidence has been increasing worldwide. These changes in prevalence cannot be explained by genetic susceptibility alone and several lifestyle changes have been linked to the rising incidence including obesity, diet and mode of delivery. Many of these environmental factors influence the composition of the gut microbiome which interacts with the immune system as well as affects gut permeability, thus...